CaV2.3 channel and PKCλ: new players in insulin secretion

16 The Journal of Clinical Investigation http://www.jci.org Volume 115 Number 1 January 2005 1. Persson, C.G. 1985. On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter. Thorax. 40:881–886. 2. Barnes, P.J. 2003. Theophylline: new perspectives for an old drug. Am. J. Respir. Crit. Care Med. 167:813–818. 3. Fredholm, B.B., and Persson, C.G. 1982. Xanthine derivatives as adenosine receptor antagonists. Eur. J. Pharmacol. 81:673–676. 4. Huszar, E., et al. 2002. Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur. Respir. J. 20:1393–1398. 5. Blackburn, M.R., et al. 2000. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. J. Exp. Med. 192:159–170. 6. Young, H.W., et al. 2004. A3 adenosine receptor signaling contributes to airway inflammation and mucus production in adenosine deaminase-deficient mice. J. Immunol. 173:1380–1389. 7. Sun, C.-X., et al. 2005. A protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury. J. Clin. Invest. 115:35–43. doi:10.1172/ JCI200522656. 8. Sajjadi, F.G., Takabayashi, K., Foster, A.C., Domingo, R.C., and Firestein, G.S. 1996. Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J. Immunol. 156:3435–3442. 9. Hasko, G., et al. 1996. Adenosine receptor agonists differentially regulate IL-10, TNFalpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J. Immunol. 157:4634–4640. 10. Le Moine, O., et al. 1996. Adenosine enhances IL-10 secretion by human monocytes. J. Immunol. 156:4408–4414. 11. Tsutsui, S., et al. 2004. A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. J. Neurosci. 24:1521–1529. 12. Johnston, J.B., et al. 2001. Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis. Ann. Neurol. 49:650–658. 13. Sandrasagra, A., et al. 2002. Discovery and development of respirable antisense therapeutics for asthma. Antisense Nucleic Acid Drug Dev. 12:177–181. 14. Nyce, J.W., and Metzger, W.J. 1997. DNA antisense therapy for asthma in an animal model. Nature. 385:721–725. 15. Peters-Golden, M. 2004. The alveolar macrophage: the forgotten cell in asthma. Am. J. Respir. Cell Mol. Biol. 31:3–7.